The historical clinical collection includes a substantial section concerning women. It describes work by a team from the T. Kirkova Obstetric-Gynecological Hospital in Sofia and separates two clinical groups: women with dysovular disturbances and infertility, and women with natural or post-castration menopausal syndrome.
Clinical groups described in the source
| Historical group | Participants | Focus of the source material |
|---|---|---|
| Group A | 51 women with diagnosed primary or secondary endocrine infertility | Ovulation-related parameters, menstrual-cycle observations, hormonal and diagnostic assessments, and comparison with other period-specific treatments. |
| Group B | 50 women with natural or post-castration menopausal syndrome | Neurovegetative and neuropsychic complaints, hot flashes, perspiration, insomnia, cardiovascular observations, libido and selected laboratory assessments. |
Selected historical table: endocrine infertility
The earlier source compares several treatment groups. The table below is presented as a historical record only. It is not a contemporary comparative recommendation.
| Historical treatment group | Participants | Normalized ovulation with pregnancy | Normalized ovulation without pregnancy | No effect | Adverse effects recorded in source table |
|---|---|---|---|---|---|
| Tribestan | 36 | 2 (5.6%) | 22 (61.1%) | 12 (33.3%) | None |
| Stimovul | 62 | 24 (38.7%) | 22 (35.5%) | 16 (25.8%) | 4 (6.6%) |
| Clostilbegite | 21 | 4 (19.0%) | 6 (28.6%) | 11 (52.4%) | 8 (38.1%) |
| Fertodur | 29 | 2 (6.9%) | 5 (17.2%) | 22 (75.9%) | 3 (10.6%) |
Selected historical table: symptoms recorded before treatment in Group B
| Symptom recorded in source | Participants | Percentage |
|---|---|---|
| Hot flashes | 50 | 100% |
| Perspiration | 39 | 78% |
| Insomnia | 41 | 82% |
| Depression | 27 | 54% |
| Hyperexcitability | 22 | 44% |
| Sense of heaviness in the cardiac region | 30 | 60% |
Modern visual summary
The chart below redraws the exact percentages from the historical Group B symptom table to make the source data easier to read. It does not add new claims.
View the original historical chart from the source collection
Important limitation
The source reflects historical clinical reporting and period-specific terminology. It should not be used to self-diagnose infertility or menopausal symptoms, to select a dose or to replace consultation with a physician.